Below we highlight selected publications from the Chronobiology and Sleep Laboratory, organized by major research themes:

Effects of sleep deprivation on cognition and wellbeing
  1. Yeo SC, Jos AM, Erwin C, Lee SM, Lee XK, Lo JC, Chee MWL, Gooley JJ. Associations of sleep duration on school nights with self-rated health, overweight, and depression symptoms in adolescents: Problems and possible solutions. Sleep Medicine. 2018; Dec 17, Epub ahead of print.
  2. Chua ECP, Fang E, Gooley JJ. Effects of total sleep deprivation on divided attention performance. PLoS One. 2017;12(11):e0187098.
  3. Huang S, Deshpande A, Yeo SC, Lo JC, Chee MWL, Gooley JJ. Short sleep impairs vocabulary learning when students cram for an exam: The Need for Sleep Study. Sleep. 2016;39(9):1681-1690.
  4. Chua ECP, Yeo SC, Lee I, Tan LC, Lau P, Tan S, Ho Mien I, Gooley JJ. Individual differences in physiologic measures are stable across repeated exposures to total sleep deprivation. Physiol Rep. 2014;2(9):e12129.
  5. Chua EC, Yeo SC, Lee I, Tan LC, Lau P, Cai S, Zhang X, Puvanendran K, Gooley JJ. Sustained attention performance during sleep deprivation associates with instability in behavior and physiologic measures at baseline. Sleep. 2014;37(1):27-39.
  6. Chua EC, Tan WQ, Yeo SC, Lau P, Lee I, Mien IH, Puvanendran K, Gooley JJ. Heart rate variability can be used to estimate sleepiness-related decrements in psychomotor vigilance during total sleep deprivation. Sleep. 2012;35(3):325-34.
Circadian rhythms, sleep, and metabolism
  1. Lo JC, Twan DCK, Karamchedu S, Lee XK, Ong JL, van Rijn E, Gooley JJ*, Chee MWL*. Differential effects of split and continuous sleep on vigilance and glucose tolerance in sleep-restricted adolescents. Sleep. 2019; Feb 12, Epub ahead of print. *Co-corresponding authors.
  2. Gooley JJ, Mohapatra L, Twan CK. The role of sleep duration and sleep disordered breathing in gestational diabetes mellitus. Neurobiol Sleep Circadian Rhythms. 2018;4:34-43. [Review article]
  3. Cai S, Tan S, Gluckman PD, Godfrey KM, Saw SM, Teoh OH, Chong YS, Meaney MJ, Kramer MS, Gooley JJ. Sleep quality and nocturnal sleep duration in pregnancy and risk of gestational diabetes mellitus. Sleep. 2017;40(2):1-8.
  4. Gooley JJ. Circadian regulation of lipid metabolism. Proc Nutr Soc. 2016;75(4):440-450. [Review article]
  5. Zhou Y, Aris IM, Tan SS, Cai S, Thway M, Krishnaswamy G, Meaney M, Godfrey KM, Kwek K, Gluckman PD, Chong YS, Yap FKP, Lek N, Gooley JJ*, Lee YS*. Sleep duration and growth outcomes across the first 2 years of life: the GUSTO study. Sleep Medicine. 2015;16(10):1281-86. *Co-corresponding authors.
  6. Chua ECP, Shui G, Cazenave-Gassiot A, Wenk MR, Gooley JJ. Changes in plasma lipids during exposure to total sleep deprivation. Sleep. 2015:38(11):1683-91.
  7. Gooley JJ and Chua ECP. Diurnal regulation of lipid metabolism and applications of circadian lipidomics. J Genet Genomics. 2014;41(5)231-250. [Review article]
  8. Chua EC, Shui G, Lee I, Lau P, Tan LC, Yeo SC, Lam BD, Bulchand S, Summers SA, Puvanendran K, Rozen SG, Wenk MR, Gooley JJ. Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes. Proc Natl Acad Sci USA. 2013;110(35):14468-73.
Non-visual photoreception
  1. Rukmini AV, Milea D, Gooley JJ. Chromatic pupillometry methods for assessing photoreceptor health in retinal and optic nerve diseases. Front Neurol. 2019;10:76. [Review Article].
  2. Rukmini AV, Milea D, Aung T, Gooley JJ. Pupillary responses to short-wavelength light are preserved in aging. Sci Rep. 2017;7:43832
  3. Rukmini AV, Milea D, Baskaran M, How A, Perera S, Aung T, Gooley JJ. Pupillary responses to high-irradiance blue light correlate with glaucoma severity. Ophthalmology. 2015;122(9):1777-85.
  4. Ho Mien I, Chua ECP, Lau P, Tan LC, Lee I, Yeo SC, Tan S, Gooley JJ. Effects of exposure to intermittent versus continuous red light on human circadian rhythms, melatonin suppression, and pupillary constriction. PLoS One. 2014;9(5):e96532.
  5. Gooley JJ, Ho Mien I, St. Hilaire MA, Yeo SC, Chua EC, Van Reen E, Hanley CJ, Hull JT, Czeisler CA, Lockley SW. Melanopsin and rod-cone photoreceptors play different roles in mediating pupillary light responses during exposure to continuous light in humans. J Neurosci. 2012;32(41):14242-53.
Dr. Gooley joined Duke-NUS Medical School in 2008 as an Assistant Professor in the Neuroscience and Behavioral Disorders Program. He is Principal Investigator of the Chronobiology and Sleep Laboratory, located in the SingHealth Investigational Medicine Unit at Singapore General Hospital. In 2005, he received his Ph.D. in Neurobiology from Harvard Medical School (HMS), where he studied neural pathways that mediate entrainment of circadian rhythms. During his postdoctoral fellowship at Brigham and Women’s Hospital (Boston, USA) and HMS, his research focused on effects of light on circadian rhythms and melatonin secretion. His current research program at Duke-NUS focuses on understanding the role of sleep and circadian rhythms in regulating human performance and physiology (link to Dr. Gooley’s publications).
© Chronobiology and Sleep Laboratory 2021